"In the beginning, God created the heavens and the earth." Genesis 1:1
God made it all, therefore it all matters. If God made it all, then it all matters to God--do you think he would waste? Even your house, before the foundations of the earth, your house, with all its leaky faucets, all its broken screen-doors, your house was set apart for you by God, that you should glorify him with it. God made everything for his own glory.
Does it matter where we live? No, God can use us anywhere, do not worry about it.
Does it matter where we live? Yes, and God has already decided it, do not worry about it.
Now, taking a step back, given that we are responsible beings, does it matter? Yes. Whatever we do, it ought to not merely be morally neutral: there is no moral neutral. It ought to be done to the glory of God. God made everything, so everything should be--will one day be--to his glory.
People are idiots, but Christ died for people anyway, and he knows better than we do how idiotic we are. We are selfish, we think we are capable of decisions that only affect a limited and predictable few people, we think we know what will bring us the most pleasure. And God tells us that he made us for so much more, and Christ died to save us from our stupidity, and the Holy Spirit opens the eyes of a chosen few to see the pleasure that can be found in glorifying God. If this were not so, we would all be fools to our deaths.
Everything matters and it all exists to the glory of God. So we must say that God made the world well, that the world is good: not now, but in the end and in the beginning. God made the earth below and the skies above: this is good. God made humans embodied beings: this is good, though I have trouble accepting it. God made mosquitoes, and mosquitoes bite us: and we deserve much worse. They take so little blood compared to what Christ shed--think on that this summer when you're scratching yourself! God made human beings male and female, and this is good, but do we really act like we believe that "and" part?
Some comments in support of homosexual marriage actually triggered this post, but let's set that aside for now. Even so, I speak here about what I do not even claim to know. How many jokes about "can't live with 'em, can't live without 'em" have you heard? How many contradictory cultural pressures are there for girls to be exaggerated girls, and guys? How many contradictory cultural pressures are there for guys to be exaggerated guys, or girls? What has even traditional marriage become? Does it presuppose that God made male and female human beings? Or do we state there that God wasted when he made Adam and said "it is not good that the man should be alone; I shall make him a helper fit for him" and then made woman, not another Adam? Do we claim by our actions and attitudes that we should have been made hermaphrodites? If so, then we call God wasteful.